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Effective Drug Found to Treat Coronavirus

Discussion in 'The Duck Hunters Forum' started by AvianQuest, Mar 19, 2020.

  1. Squaller

    Squaller Elite Refuge Member

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    So... You're saying it won't work?

    It is my understanding that hydroxychloroquine does NOT kill the virus, it just interupts the receptors of the virus from binding properly... It would also appear that there is potential anti-inflammatory benefits from the drug.

    As I understand it, it is not the virus itself that causes the issues but our own inflammatory response to the virus. So, hydroxychloroquine reduces the virus's ability to bind to our cells, and it potentially reduces the inflammatory response our body has to the virus.... It does NOT kill the virus. But it does look to be a potentially beneficial treatment, and possible preventative to the virus... VERY GOOD NEWS...

    (Someone please correct me if I am incorrect).

    Currently, I feel that widespread testing would greatly benefit in getting people back to work, and isolating infected/treating people. One of the biggest factors causing the hysteria, is that this virus can be spread rapidly from people with few or no symptoms...

    Currently we only have three cases of confirmed cases in Fresno County (all from travelers)... But with limited testing, we really have no idea what those numbers really are, and who is spreading it.
     
    Wareagle1 and Truman like this.
  2. J.Bennett

    J.Bennett Elite Refuge Member

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    Oh, it might work, but it's more likely to kill you than Covid-19...
     
  3. Native NV Ducker

    Native NV Ducker Mod-Duck Hunters Forum, Classifieds, and 2 others Moderator

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    Man alive. There is some hi-folutin medical analysis going on here at the 'Fuge.

    Carry on.
     
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  4. Phytoplankton

    Phytoplankton Elite Refuge Member

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    So far the test sample is way too small to start whistling rainbows and calling it an effective treatment, promising perhaps (and hopefully), but how many times have we all heard that there is a drug in testing for cancer, ALS, diabetes, etc., and then it doesn't pan out.
     
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  5. bang you'r dead

    bang you'r dead Canada Forum Mod. Eh! Moderator

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    Here are the referenced scientific articles, rather than getting it third hand. Medline/PubMed search function.

    1. Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., … & Xiao, G. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell research, 30(3), 269-271. (In vitro means in the test tube, NOT tested in humans-Warren) https://www.nature.com/articles/s41...nkrL6i6fJcWwi0ygN1LtI67SkcgREM4DyxxAcPauRuf5w


    1. Gao, J., Tian, Z., & Yang, X. (2020). Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. BioScience Trends.
      BioScience Trends. 2020;14(1):72-73. (DOI: 10.5582/bst.2020.01047)

      Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
      Gao JJ, Tian ZX, Yang X


      SUMMARY
      The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.


      KEYWORDS: COVID-19, SARS-CoV-2, 2019-nCoV, pneumonia, chloroquine

    BioScience Trends. 2020;14(1):69-71. (DOI: 10.5582/bst.2020.01020)

    Drug treatment options for the 2019-new coronavirus (2019- nCoV)
    Lu HZ


    SUMMARY
    As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), arbidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. However, the efficacy and safety of these drugs for 2019- nCoV still need to be further confirmed by clinical experiments.


    KEYWORDS: 2019-nCoV, Coronaviruses, pneumonia

    BioScience Trends. 2020;14(1):64-68. (DOI: 10.5582/bst.2020.01030)

    Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment
    Wang ZW, Chen XR, Lu YF, Chen FF, Zhang W


    SUMMARY
    Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection. Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study.


    KEYWORDS: 2019-nCoV, lopinavir, ritonavir, arbidol, Shufeng Jiedu Capsule



    1. Yao, X., Ye, F., Zhang, M., Cui, C., Huang, B., Niu, P.. & Zhan, S. (2020). In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
    I only gave a quick read, but remember that none of these have been peer reviewed, and the studies were not apparently double blinded, so the data may be skewed.
     
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  6. Squaller

    Squaller Elite Refuge Member

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    Hopefully you understand that there was an invisible "sarcasm icon" on my post.

    I do have some time if you would like to work together to develop a chloroquine beer product... We could call it "Corona Killer." Add some orange or lime for more vitamin C....
     
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  7. AvianQuest

    AvianQuest Elite Refuge Member

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    It's certainly not going to kill you. It kept me from getting all kinds of bad stuff while in the British Army Free Fire Zone in the jungles of Belize. Although the FDA hasn't approved it for coronavirus since it's a new virus, hydroxychloroquine can legally be prescribed by a physician to treat or prevent the coronavirus and it's being used as we speak.
     
  8. Luigi Daniele

    Luigi Daniele Turkey Hunters Forum Moderator

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    And apparently already has kept severe cases from becoming deadly. HOTR
     
  9. TheDuckSlayer

    TheDuckSlayer Elite Refuge Member

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    he’s talking about drinking several gallons of tonic water (to get the necessary dosage of quinine) killing you via water intoxication.

    for someone who copies and pastes so much, one would think you could read better.
     
  10. WHUP ! Hen

    WHUP ! Hen Elite Refuge Member Supporting Member

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    Everyone who was in Southeast Asia are familiar with these. Every day we took a little white pill and on Friday’s took a big orange one, suppose to keep you from getting malaria. I guess they must have worked because I was bit by 10,000 or more mosquitos, and didn’t get malaria.
     

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